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The functional tissue of the spleen… The spleen is encased in a thick connective-tissue capsule. One of its main functions is to bring blood into contact with lymphocytes. Learn More in these related Britannica articles: The white pulp of the spleen contains typical lymphoid elements, such as plasma cells, lymphocytes , and lymphatic nodules, called follicles in the spleen.
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Similar to the lymph nodes, the spleen reacts to microorganisms and other antigens that reach the bloodstream by releasing special phagocytic cells known as macrophages. In animals who have had their spleens removed, the monocyte response is not observed at the site of tissue injury, and healing is less thorough.
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